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Amoxicillin + clavulanic acid
Essential medicine status
General description
Amoxicillin is an extended spectrum penicillin antibiotic. Clavulanic acid is a beta-lactamase inhibitor.
INN
Amoxicillin + clavulanic acid
ATC codes
J01CR02
Medicine type
Chemical agent
Antibiotic groups
ACCESS
EML status history
Added in 2017 (TRS 1006) for Acute otitis media
Added in 2017 (TRS 1006) for Infectious cystitis
Added in 2017 (TRS 1006) for Acute sinusitis
Added in 2017 (TRS 1006) for Neutropenia
Added in 2017 (TRS 1006) for Peritoneal abscess
Added in 2017 (TRS 1006) for Peritonitis
Added in 2017 (TRS 1006) for Bacterial pneumonia
Wikipedia
Amoxicillin + clavulanic acid
DrugBank
Amoxicillin ,
Clavulanic acid (Clavulanate)
Recommendations
Section
Access group antibiotics
  • Parenteral > General injections > IV: 500 mg (as sodium salt) + 100 mg (as potassium salt) powder for injection; 1000 mg (as sodium salt) + 200 mg (as potassium salt) powder for injection
  • Oral > Solid > tablet: 500 mg (as trihydrate) + 125 mg (as potassium salt)
  • Oral > Liquid: 125 mg (as trihydrate) + 31.25 mg (as potassium salt) / 5 mL powder for oral liquid; 250 mg (as trihydrate) + 62.5 mg (as potassium salt) / 5 mL powder for oral liquid
  • Oral > Solid > dispersible tablet: 200 mg (as trihydrate) + 28.5 mg (as potassium salt); 250 mg (as trihydrate) + 62.5 mg (as potassium salt)
  • Oral > Solid > tablet: 500 mg (as trihydrate) + 125 mg (as potassium salt); 875 mg (as trihydrate) + 125 mg (as potassium salt)
Indications
First choice
Peritonitis (mild-moderate) Bacterial pneumonia (Community-acquired pneumonia - severe) [children] Other specified pneumonia (Hospital-acquired pneumonia) Peritoneal abscess (mild-moderate) Neutropenia (low-risk) Infectious cystitis Acute sinusitis Bacterial cellulitis, erysipelas or lymphangitis Chronic obstructive pulmonary disease with acute exacerbation
Second choice
Other specified prophylactic measures Bacterial pneumonia (Community-acquired pneumonia - mild to moderate) Acute otitis media Osteomyelitis or osteitis Bacterial infection of joint co-prescribed with clarithromycin Bacterial pneumonia (Community-acquired pneumonia - severe)
Other indications
Bacterial infection of unspecified site
Section
Antituberculosis medicines
  • Oral > Liquid: 250 mg (as trihydrate) + 62.5 mg (as potassium salt) / 5 mL powder for oral liquid
  • Oral > Solid > tablet: 500 mg (as trihydrate) + 125 mg (as potassium salt)
Indications
Multi-drug resistant Mycobacterium tuberculosis