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ATC codes: J05AE01
EMLc
Indication
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecified ICD11 code: 1C62.Z
INN
Saquinavir
Medicine type
Chemical agent
List type
Core (EML)
(EMLc)
Formulations
Oral > Solid: 200 mg ; 500 mg
EML status history
First added in 2002 (TRS 914)
Changed in 2007 (TRS 950)
Changed in 2009 (TRS 958)
Removed in 2017 (TRS 1006)
Sex
All
Age
Also recommended for children
Weight restriction
> 25 kg
Therapeutic alternatives
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Wikipedia
DrugBank
Summary of evidence and Expert Committee recommendations
The Expert Committee recommended the deletion of saquinavir from the Model Lists, noting that that clinical use of the protease inhibitor saquinavir has declined over time with the introduction of newer antiretroviral agents with lower pill burden, similar or greater effectiveness and lower risk of toxicity. Unlike other protease inhibitors, saquinavir is associated with QT prolongation and a requirement for ECG monitoring. Numerous alternative protease inhibitors (with and without ritonavir) remain listed on the EML.