Export

EN
FR
ATC codes: N07AA01
EMLc
Indication
Anticholinesterase reversible ICD11 code: XM9D92
INN
Neostigmine bromide
Medicine type
Chemical agent
List type
Core (EML)
(EMLc)
Formulations
Oral > Solid: 15 mg (neostigmine bromide)
Parenteral > General injections > unspecified: 0.5 mg per mL in 1 mL ampoule (neostigmine metilsulfate) ; 2.5 mg per mL in 1 mL ampoule (neostigmine metilsulfate)
EML status history
First added in 1977 (TRS 615)
Changed in 1979 (TRS 641)
Changed in 1989 (TRS 796)
Changed in 2003 (TRS 920)
Changed in 2007 (TRS 950)
Sex
All
Age
Also recommended for children
Therapeutic alternatives
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Wikipedia
DrugBank
Summary of evidence and Expert Committee recommendations
The EMLc Subcommittee noted that neostigmine metilsulfate injection was the preferred agent for the reversal of non-depolarising muscle block and endorsed neostigmine injection for inclusion in the EMLc. While neostigmine bromide tablets are licensed for use in infants and children for the treatment of myasthenia gravis, the Subcommittee noted that pyridostigmine has fewer cholinergic adverse effects and is now regarded as the first-line drug treatment for myasthenia gravis. The Subcommittee endorsed neostigmine (injection and tablet forms) and pyridostigmine (injection and tablet forms) for inclusion in the EMLc, with the latter retained in the Complementary List.