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Eflornithine
Essential medicine status
Section:
6. Anti-infective medicines 6.5. Antiprotozoal medicines 6.5.5. Antitrypanosomal medicines 6.5.5.1. African trypanosomiasis 6.5.5.1.2. Medicines for the treatment of 2nd stage African trypanosomiasis
ATC codes: P01CX03
EMLc
Indication
African trypanosomiasis ICD11 code: 1F51
INN
Eflornithine
Medicine type
Chemical agent
List type
Core (EML)
(EMLc)
Additional notes
To be used for the treatment of Trypanosoma brucei gambiense infection.
Formulations
Parenteral > General injections > IV: 200 mg per mL in 50 mL bottle (hydrochloride)
EML status history
First added in 1991 (TRS 825)
Changed in 2007 (TRS 946)
Changed in 2007 (TRS 950)
Changed in 2023 (TRS 1049)
Sex
All
Age
Also recommended for children
Therapeutic alternatives
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Wikipedia
Eflornithine
DrugBank
Eflornithine
Summary of evidence and Expert Committee recommendations
Following the review of the age-appropriateness of formulations on the EMLc, the Expert Committee recommended the listing for eflornithine on the EML and EMLc be amended to change the bottle volume in which eflornithine is supplied from 100 mL to 50 mL.