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Midazolam
Essential medicine status
General description
Midazolam is a benzodiazepine with a wide range of effects including anxiolytic, sedative, muscle relaxant, antiepileptic and anterograde amnesic.
INN
Midazolam
ATC codes
Medicine type
Chemical agent
EML status history
First added in 2009 (TRS 958) for Palliative care
Added in 2015 (TRS 994) for Status epilepticus
Changed in 2021 (TRS 1035) for Status epilepticus
Therapeutic equivalent for
Wikipedia
DrugBank
Recommendations
Section
Preoperative medication and sedation for short-term procedures
  • Parenteral > General injections > IV: 1 mg per mL
  • Oral > Liquid: 2 mg per mL
  • Oral > Solid > dosage form: 15 mg; 7.5 mg
Section
Medicines for other common symptoms in palliative care
  • Oral > Liquid: 2 mg per mL
  • Parenteral > General injections > unspecified: 1 mg per mL; 5 mg per mL
  • Oral > Solid > dosage form: 7.5 mg; 15 mg
Indications
Section
Antiseizure medicines
  • Parenteral > General injections > unspecified: 1 mg per mL in 5 mL vial (for buccal administration); 5 mg per mL in 1 mL vial (for buccal administration); 5 mg per mL in 3 mL vial (for buccal administration)
  • Local > Buccal > Solution: 5 mg per mL in 0.5 mL pre-filled syringe (for oromucosal administration); 5 mg per mL in 1 mL pre-filled syringe (for oromucosal administration); 5 mg per mL in 1.5 mL pre-filled syringe (for oromucosal administration); 5 mg per mL in 2 mL pre-filled syringe (for oromucosal administration); 10 mg per mL in 0.25 mL pre-filled syringe (for oromucosal administration); 10 mg per mL in 0.5 mL pre-filled syringe (for oromucosal administration); 10 mg per mL in 0.75 mL pre-filled syringe; 10 mg per mL in 1 mL pre-filled syringe (for oromucosal administration)