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Cyclophosphamide
Essential medicine status
General description
Cyclophosphamide is an antineoplastic alkylating agent, used in the treatment of many cancers.
INN
Cyclophosphamide
ATC codes
L01AA01
Medicine type
Chemical agent
EML status history
First added in 1977 (TRS 615) for Diffuse large B-cell lymphomas
Added in 1977 (TRS 615) for Follicular lymphoma
Added in 1977 (TRS 615) for Hodgkin lymphoma
Added in 2019 (TRS 1021) for Plasma cell myeloma
Wikipedia
Cyclophosphamide
DrugBank
Cyclophosphamide
Recommendations
Section
Cytotoxic medicines
  • Parenteral > General injections > IV: 500 mg in vial powder for injection; 1 g in vial powder for injection; 2 g in vial powder for injection
  • Oral > Solid: 25 mg; 50 mg
  • Oral > Solid: 25 mg tablet
  • Parenteral > General injections > unspecified: 500 mg in vial powder for injection
  • Oral > Solid: 25 mg; 50 mg tablet
Indications
Diffuse large B-cell lymphomas Chronic lymphocytic leukaemia or small lymphocytic lymphoma Malignant neoplasms of breast Malignant trophoblastic neoplasms of placenta Follicular lymphoma Other specified malignant neoplasms of breast Hodgkin lymphoma Rhabdomyosarcoma primary site Ewing sarcoma of bone and articular cartilage of unspecified sites Lymphoid leukaemia, not elsewhere classified Burkitt lymphoma including Burkitt leukaemia Unspecified malignant neoplasms of ill-defined or unspecified sites Plasma cell myeloma Other specified gliomas of brain Malignant neoplasms of kidney, except renal pelvis Anaplastic large cell lymphoma, ALK-positive Anaplastic large cell lymphoma, ALK-negative