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Protamine sulfate
Essential medicine status
Section:
10. Medicines affecting the blood 10.2. Medicines affecting coagulation
ATC codes: V03AB14
EMLc
Indication
Haemorrhagic disorder due to circulating anticoagulants or coagulation factors inhibitors ICD11 code: 3B21
INN
Protamine sulfate
Medicine type
Chemical agent
List type
Core (EML)
Complementary (EMLc)
Formulations
Parenteral > General injections > IV: 10 mg per mL in 5 mL ampoule or vial
EML status history
First added in 1977 (TRS 615)
Changed in 1979 (TRS 641)
Changed in 1984 (TRS 722)
Changed in 2007 (TRS 950)
Changed in 2025 (TRS 1064)
Sex
All
Age
Also recommended for children
Therapeutic alternatives
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Wikipedia
Protamine sulfate
DrugBank
Protamine sulfate
Summary of evidence and Expert Committee recommendations
Following the review of the age-appropriateness of formulations on the EMLc, the Expert Committee recommended: - to modify the formulation descriptions to better describe the available dosage forms.