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Alprostadil (prostaglandin E1)
Essential medicine status
Section:
22. Medicines for reproductive health and perinatal care 22.7. Medicines administered to the neonate [c]
ATC codes: C01EA01
EMLc
Indication
Other specified congenital anomaly of great arteries including arterial duct ICD11 code: LA8C.Y
INN
Alprostadil
Medicine type
Chemical agent
List type
Complementary (EML)
(EMLc)
Formulations
Parenteral > General injections > IV: 0.5 mg per mL in alcohol (EMLc)
EML status history
First added in 2009 (TRS 958)
Changed in 2021 (TRS 1035)
Changed in 2025 (TRS 1064)
Sex
All
Age
Newborn (< 1 month)
Therapeutic alternatives
dinoprostone (prostaglandin E2) (ATC codes: G02AD02)
Parenteral > General injections > IV: 1 mg per mL
Patent information
Patents have expired in most jurisdictions
Wikipedia
Alprostadil (prostaglandin E1)
DrugBank
Prostaglandin e (Alprostadil)
Summary of evidence and Expert Committee recommendations
Following the review of the age-appropriateness of formulations on the EMLc, the Expert Committee recommended updating the medicine descriptions for prostaglandin E1 and E2 to reflect active ingredients by international non-proprietary names (alprostadil and dinoprostone).