Export

EN
FR
Ethambutol + isoniazid
Not recommended as an essential medicine
Section:
6. Anti-infective medicines 6.2. Antibacterials 6.2.5. Antituberculosis medicines
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ATC codes: J04AM03
Indication
Tuberculosis ICD11 code: 1B4Z
INN
Ethambutol + isoniazid
Medicine type
Chemical agent
List type
Core
Formulations
Oral > Solid: 400 mg + 150 mg tablet
EML status history
First added in 1997 (TRS 882)
Removed in 2019 (TRS 1021)
Sex
All
Age
Adolescents and adults
Therapeutic alternatives
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Wikipedia
Ethambutol + isoniazid
DrugBank
Ethambutol ,
Isoniazid
Summary of evidence and Expert Committee recommendations
The Expert Committee recommended the deletion of ethambutol + isoniazid (HE) fixed-dose combination formulation from the core list of the EML, noting the advice of the WHO Global TB Programme that its use is no longer recommended in current WHO guidelines based on evidence that treatment regimens involving this formulation have been associated with greater rates of relapses and death than alternative treatments. The 2010 WHO Treatment of tuberculosis guidelines guidelines for the treatment of tuberculosis (1) recommended that the two-month rifampicin regimen, 2HRZE/6HE, should be phased out, based on evidence that showed it to be associated with more relapses and deaths than the six-month rifampicin regimen, 2HRZE/4HR.