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Codes ATC: J05AF01
EMLc
Indication
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecified Code ICD11: 1C62.Z
INN
Zidovudine
Type de médicament
Chemical agent
Type de liste
Liste de base (EML)
(EMLc)
Formulations
Parenteral > General injections > IV: 10 mg per mL in 20 mL vial solution for IV infusion (EML)
Oral > Liquid: 50 mg per 5 mL
Oral > Solid > tablet: 300 mg (EML)
Oral > Solid > capsule: 250 mg (EML)
Historique des statuts LME
Ajouté pour la première fois en 1997 (TRS 882)
Modifié en 2002 (TRS 914)
Modifié en 2007 (TRS 950)
Modifié en 2015 (TRS 994)
Modifié en 2017 (TRS 1006)
Modifié en 2019 (TRS 1021)
Sexe
Tous
Âge
Aussi recommandé pour les enfants
Restriction de poids
> 3 kg
Équivalence thérapeutique
La recommandation concerne ce médicament spécifique
Renseignements sur le brevet
Patents have expired in most jurisdictions
Lire la suite sur les brevets.
Wikipédia
DrugBank
Résumé des preuves et recommandation du comité d'experts
The Committee recommended deletion of zidovudine 60 mg dispersible scored tablet from the EMLc, noting they are no longer included in the current WHO guidelines for paediatric HIV treatment, and that suitable alternatives are already included on the Model Lists and available for use. Zidovudine oral solution 50 mg/5mL remains included on the Model Lists for postnatal prophylaxis or neonatal use. Zidovudine in fixed-dose combination with nevirapine and/or lamivudine remains included on the Model Lists. Recommendations were made by the WHO HIV Department to delete the antiretroviral formulations from the EML and EMLc in order to achieve alignment between the 2018 WHO interim guidelines for antiretroviral regimens (1), and The 2018 optimal formulary and limited-use list for paediatric ARVs (2). Zidovudine (AZT) 60 mg dispersible scored tablet was removed from the latest limited-use list. Zidovudine 60 mg is available in dual fixed-dose combination formulations with lamivudine that can be combined with an abacavir 60 mg dispersible scored tablet to deliver a triple nucleoside regimen during TB treatment.