Export

EN
FR
Silver nitrate
Not recommended as an essential medicine
Section:
21. Ophthalmological preparations 21.1. Ophthalmological preparations > Anti-infective agents
Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed Removed
ATC codes: D08AL01
Indication
Neonatal conjunctivitis or dacryocystitis ICD11 code: KA65.0
Medicine type
Chemical agent
List type
Core
Formulations
Local > Ophthalmological > Solution (eye drops): 1%
EML status history
First added in 1977 (TRS 615)
Changed in 1979 (TRS 641)
Removed in 2005 (TRS 933)
Sex
All
Age
Adolescents and adults
Therapeutic alternatives
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Wikipedia
Silver nitrate
DrugBank
Silver nitrate
Summary of evidence and Expert Committee recommendations
During its meeting in 2003, the Committee recommended that silver nitrate eye solution be reviewed for possible fast-track deletion at the meeting in 2005. A review was received from the ISDB, and a comment was received from the WHO Department of Chronic Diseases, Prevention and Management. The Committee noted that there was inadequate evidence on the safety of silver nitrate eye solution in the prevention of neonatal gonococcal conjunctivitis. The ISDB and the WHO Department of Chronic Diseases, Prevention and Management both raised safety concerns and supported the deletion of this item from the Model List. The aqueous solutions had caused chemical conjunctivitis due to the evaporation of the solvent over time, especially in tropical conditions, and such conjunctival irritation hampered eye contact of the neonate with the mother, which was claimed to hinder bonding. The Committee also noted that tetracycline ointment, which is already in the Model List, can be used for the same indications with fewer unwanted effects. The Committee therefore recommended that silver nitrate eye solution be deleted from the Model List.