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ATC codes: C09BA03
Indication
Essential hypertension ICD11 code: BA00.Z
INN
Lisinopril + hydrochlorothiazide
Medicine type
Chemical agent
List type
Core
Formulations
Oral > Solid: 10 mg + 12.5 mg ; 20 mg + 12.5 mg ; 20 mg + 25 mg
EML status history
Application rejected in 2017 (TRS 1006)
Added in 2019 (TRS 1021)
Changed in 2021
Sex
All
Age
Adolescents and adults
Therapeutic alternatives
Medicines within the same pharmacological class can be used
Therapeutic alternatives limitations
Therapeutic alternatives are medicines in the 4th level ATC chemical subgroup C09AA ACE inhibitors, plain (for lisinopril); and chlorothiazide, chlortalidone and indapamide (for hydrochlorothiazide)
Patent information
Patents have expired in most jurisdictions
Summary of evidence and Expert Committee recommendations
Following the review of square box listings on the EML and EMLc, the Expert Committee recommended that fixed-dose combinations of medicines in 4th level ATC chemical subgroup, C09AA ACE inhibitors, plain (for lisinopril) and chlorothiazide, chlortalidone and indapamide (for hydrochlorothiazide), be specified as therapeutic alternatives under the square box listing for lisinopril + hydrochlorothiazide on the EML.