The Expert Committee did not recommend the inclusion of sub-cutaneous injection formulations of methotrexate on the EML and EMLc for the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriasis and arthritic psoriasis and Crohn disease in patients not responding to maximum tolerable doses of oral methotrexate. The Committee noted that methotrexate is one of the mainstays of treatment for these conditions, but that data on clinical efficacy and safety of subcutaneous methotrexate compared to oral or intramuscular formulations are limited and are based mostly on studies in patients with rheumatoid arthritis. Overall, the Committee considered the possible benefits of subcutaneous compared to oral methotrexate were unclear, and with limited available evidence suggesting only modest benefits in a small proportion of patients, at a considerably higher price.