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ATC codes: G02CB03
Indication
Other specified benign neoplasm of endocrine glands ICD11 code: 2F37.Y
INN
Cabergoline
Medicine type
Chemical agent
List type
Core
Formulations
Oral > Solid > tablet: 0.5 mg ; 1 mg
EML status history
First added in 2023 (TRS 1049)
Sex
All
Age
Adolescents and adults
Therapeutic alternatives
Patent information
Patents have expired in most jurisdictions
Wikipedia
DrugBank
Summary of evidence and Expert Committee recommendations
The Expert Committee recommended the inclusion of cabergoline on the core list of the EML for the medical management of hyperprolactinaemia associated with prolactin-secreting pituitary adenomas (prolactinomas). Listing was recommended with bromocriptine as a therapeutic alternative under a square box listing. Overall, the Committee considered that the available evidence suggests medical therapy with dopamine agonists can achieve prolactin normalization in most patients. The Committee noted that dopamine agonist therapy is a preferred first-line intervention for management of hyperprolactinaemia and prolactinomas and may be the only option in settings where specialist neurosurgery is not available, or in patients for whom surgery is not feasible. Listing was recommended with bromocriptine as therapeutic alternative under a square box listing. Cabergoline may be superior to bromocriptine in decreasing the serum prolactin concentration and has fewer adverse effects but is usually more costly.