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Liraglutide
The Expert Committee, after evaluation, declines to list the medicine proposed in the application.
The Model List of Essential Medicines reports reasons that Committee Members have identified for denying listing.
Rejected
Section:
18. Medicines for endocrine disorders
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Rejected
ATC codes: A10BJ02
Indication
Obesity ICD11 code: 5B81.Z
INN
Liraglutide
Medicine type
Chemical agent
List type
Core
Formulations
Parenteral > General injections > SC: 6 mg per mL in 3 mL pre-filled pen
EML status history
Application rejected in 2023 (TRS 1049)
Sex
All
Age
Adolescents and adults
Therapeutic alternatives
Medicines within the same pharmacological class can be used
Therapeutic alternatives limitations
Therapeutic alternatives are medicines in the 4th level ATC chemical subgroup: A10BJ Glucagon-like peptide-1 (GLP-1) analogues
Patent information
Main patents have expired but secondary patents might remain active in some jurisdictions. For more information on specific patents and license status for developing countries visit www.MedsPal.org
Wikipedia
Liraglutide
DrugBank
Liraglutide
Summary of evidence and Expert Committee recommendations
The Expert Committee did not recommend inclusion of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to the core list of the EML for weight loss in obesity because of uncertain long-term clinical benefit and safety in this patient population. The Committee noted that GLP-1 RAs have been shown to reduce weight and body mass index in the short-term compared to placebo. However, data are lacking on long-term effectiveness, optimal duration of treatment, maintenance of weight reduction once the therapy is stopped, and effect on other clinically important outcomes (e.g. hypertension or hyperglycaemia). Long-term safety data are also lacking.