Anaemia due to chronic disease ICD11 code: 3A71
Parenteral > General injections > unspecified: 1000 IU per 0.5 mL pre-filled syringe ; 2000 IU per 0.5 mL pre-filled syringe ; 3000 IU per 0.3 mL pre-filled syringe ; 4000 IU per 0.4 mL pre-filled syringe ; 5000 IU per 0.5 mL pre-filled syringe ; 6000 IU per 0.6 mL pre-filled syringe ; 8000 IU per 0.8 mL pre-filled syringe ; 10000 IU per 1 mL pre-filled syringe ; 20000 IU per 0.5 mL pre-filled syringe ; 40000 IU per 1 mL pre-filled syringe
EML status history
Also recommended for children
Patents have expired in most jurisdictions
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Expert Committee recommendation
The Expert Committee noted that erythropoiesis-stimulating agents have been shown to be an effective medication for treating anaemia in children, young people and adults with chronic renal disease requiring dialysis and that there are no alternative medicines already included in the EML and EMLc for this indication. It also noted that biosimilars for erythropoiesis-stimulating agents have been shown to be a valid alternative to the reference products. Considering all important clinical outcomes, the Committee considered that there is a relevant benefit resulting from erythropoiesis-stimulating agents. Based on the positive evaluation, the Committee therefore recommended erythropoiesis-stimulating agents be included in the complementary list of the EML and EMLc. The Expert Committee recommended listing erythropoiesis-stimulating agents with a square box to represent the class and inclusion of a note limiting alternatives to epoetin alfa, beta and theta, darbepoetin alfa, methoxy polyethylene glycol-epoetin beta and their respective biosimilars (EML) and epoetin alfa, beta and theta, darbepoetin alfa, and their respective biosimilars (EMLc).
The antianaemia medicines currently included in the EML are: ferrous salt, ferrous salt + folic acid, folic acid, and hydroxocobalamin (4).
Public health relevance
Chronic kidney disease is defined as the presence of kidney damage (usually detected as urinary albumin excretion ≥30 mg/day, or equivalent) or reduced kidney function (defined as estimated glomerular filtration rate (GFR) <60 mL/min per 1.73 m2) for 3 or more months, irrespective of the cause. The prognosis for chronic kidney disease and the need for renal replacement therapy (either dialysis or kidney transplant) depend on: the cause of chronic kidney disease; GFR category; albuminuria category; and other risk factors and comorbid conditions (e.g. hypertension, hyperglycaemia, dyslipidaemia, smoking, obesity, history of cardiovascular disease) (2). End-stage renal disease refers to people with stage 5 chronic kidney disease undergoing dialysis and to recipients of kidney transplants. The KDIGO (Kidney Disease: Improving Global Outcomes) initiative recommends beginning dialysis as soon as life-threatening changes occur in fluid, electrolyte and acid–base balance; these usually happen when GFR is 5–10 mL/min per 1.73 m2. Specifically, starting dialysis is suggested when at least one of the following occurs: • signs or symptoms of renal failure, such as serositis, acid–base or electrolyte abnormalities, pruritus • inability to control volume status • inability to control blood pressure • malnutrition not responsive to dietary interventions • cognitive impairment. Anaemia is one of the most serious complications of chronic kidney disease and end-stage renal disease. Normochromic normocytic anaemia is due mainly to erythropoietin deficiency which itself is caused principally by reduced renal erythropoietin production, presumably reflecting the reduction in the number of erythropoietin-producing cells in the kidneys. To a lesser degree, it is caused by the shortened red cell lifespan. Erythropoietin is the hormone responsible for maintaining the proliferation and differentiation of erythroid progenitor cells in the bone marrow, and renal anaemia can thus be regarded as a hormone deficiency state. According to WHO (5) anaemia is to be diagnosed when Hb falls below: • 13 g/dL (130 g/L) in men ≥15 years old • 12 g/dL (120 g/L) in non-pregnant women ≥15 years old or adolescents aged 12–14 years • 11.5 g/dL (115 g/L) in children aged 5–11 years • 11 g/dL (110 g/L) in pregnant women, or children aged 6-59 months. If left untreated, anaemia in chronic kidney disease may cause deterioration in cardiac function, poor cognition and mental acuity, and fatigue. There are also associations with an increased risk of morbidity and mortality, principally due to cardiac disease and stroke (6). Chronic kidney disease affects approximately 8–16% of the adult population worldwide (7). The overall lifetime incidence of chronic kidney disease rises with age, with approximately 50% of Stage 3a+ incidents occurring after age 70 years. The overall lifetime incidence of end-stage renal disease has been estimated at 3.6% (8). The incidence and prevalence of chronic kidney disease seem remarkably consistent globally, if not always well documented, whereas the distribution of those receiving renal replacement therapies (dialysis and transplantation) varies by country. About 2.2 million people receive dialysis globally, projected to be 5.4 million by 2030 (9). Anaemia is one of the several complications of chronic kidney disease. Its prevalence (from any cause) in patients with renal failure is about 15% in USA (10). In chronic kidney diseases end stages, about half of all patients are severely anaemic. The main impact of anaemia on organ function is reduced oxygen delivery to tissues, leading to debilitating symptoms such as fatigue, exercise intolerance, impaired cognitive function, sleep disorder, altered haemostasis, and depressed immune function. Anaemia in patients with chronic kidney disease is associated with decreases in cardiac and renal functions and impaired quality of life and poses a significant clinical and economic burden on health-care systems. Anaemia is also associated with a high prevalence of cardiovascular diseases in renal patients, with consequent higher morbidity and mortality: cardiovascular diseases are reported to account for more than 50% of deaths in these patients (11). In children, iron deficiency and Hb lower than 11.8 g/dL (118 g/L) have also been associated with cognitive impairment (12).
The application summarizes evidence on the effectiveness and safety of ESAs, including branded medicinal products and biosimilars, for the treatment of anaemia in end-stage chronic kidney disease in adults and children undergoing dialysis. The review includes up-to-date systematic reviews of randomized controlled trials (RCTs) and other types of evidence syntheses (e.g. health technology assessment (HTA) reports, clinical guidelines if developed following a systematic approach) and pharmacoeconomic analyses comparing erythropoietins (epoetin alfa, beta, theta, zeta), darbepoetin alfa, and CERA with: • no intervention, placebo, standard care • other ESAs • other interventions (e.g. iron supplementation, androgen) • different dosages and administration schedules of the same ESA • branded versus biosimilar products. Eight systematic reviews (13–20), three clinical guidelines (1, 6, 21), two HTA reports (22, 23) , five cost-analyses (described in the Costs section), one RCT published in 2015 but not included in the evidence synthesis reports (24) and one meta-regression study (25) were included. Adults Several sources of information provided useful information (16, 18, 20, 24), but the main source was a 2014 network meta-analysis that summarizes 56 studies for a total of 15 596 participants (17). This compared the efficacy and safety of different ESAs (epoetin alfa and beta, darbepoetin alfa, or CERA, and biosimilar ESAs, with each other, with placebo or with no treatment). Epoetin alfa and beta vs placebo/no treatment/standard care (see Summary of Findings 1) The evidence suggests that there are no differences in all-cause mortality and major cardiovascular events (stroke, myocardial infarction), presumably because of a paucity of data on these outcomes. Epoetin alfa and beta consistently reduced the risk of requiring blood transfusions. They do not appear to affect the risk of vascular access thrombosis but increase the risk of hypertension. The quality of evidence was judged to be low for all-cause mortality, major cardiovascular events and vascular access thrombosis because of the unclear risk of selection bias and the imprecision of the estimates. The effect of epoetin alfa and beta in reducing the number of blood transfusions and increasing the risk of hypertension was supported by high-quality evidence. However unclear, the risk of selection bias appears negligible in the light of the magnitude of these effects. These results seem to be consistent between industry-sponsored and other sponsorship trials. Darbepoetin vs other ESAs (epoetin alfa and beta, CERA) (see Summary of Findings 2) There is no evidence of a difference between darbepoetin and other ESAs (epoetin alfa, beta, CERA) in terms of all-cause mortality, major cardiovascular events (stroke, myocardial infarction), hypertension, vascular access thrombosis and Hb levels. The evidence suggests that darbepoetin reduces the risk of requiring blood transfusions compared with epoetin alfa but not with CERA. The quality of evidence was judged to be very low to moderate, mainly because of the unclear risk of selection bias, the imprecision of the estimates and the suspicion of selective reporting of outcomes. It is worthy of note that the effect of darbepoetin in reducing blood transfusions was supported by high-quality evidence. These results were driven largely by industry-sponsored trials. CERA vs epoetin alfa and beta (see Summary of Findings 3) CERA appears to be similar to epoetin alfa and beta in terms of all the outcomes evaluated. However, the quality of evidence supporting these findings was judged to be very low and low because of the unclear risk of selection bias, the imprecision of the estimates and the suspicion of selective reporting of outcomes. These results were driven largely by industry-sponsored trials. Originators (epoetin alfa) vs biosimilars (see Summary of Findings 4) There were no differences between the originator epoetin alfa and its biosimilars in terms of all-cause mortality, major cardiovascular events (stroke, myocardial infarction), blood transfusions and vascular access thrombosis. The risk of hypertension seemed lower with biosimilars. The quality of evidence was generally judged to be low because of the unclear risk of selection bias and the imprecision of the estimates; the exception was the findings on hypertension, supported by evidence of moderate quality due only to unclear risk of selection bias. These results appear to be consistent between industry-sponsored and other sponsorship trials. Quality of life A systematic review updated to November 2015 specifically assessed the effect of achieving higher Hb targets on quality of life of patients with chronic kidney disease, including those undergoing dialysis (14). Of the 17 studies considered, 12 were in the non-dialysis population, four in the dialysis population, and one in a combined sample. Overall, the review showed that higher versus lower Hb targets resulted in only small and, in many cases, nonsignificant changes in scores of several health-related quality-of-life tools, both in the overall population and in the 2433 patients undergoing dialysis. In the latter subgroup, differences in physical functioning, vitality and social functioning measured as components of SF-36 (36-Item Short Form Health Survey) were 1.65 (95% confidence interval (CI) −7.22 to 10.52), −1.73 (95% CI −13.95 to 10.49), and −0.70 (95% CI −21.19 to 19.79), respectively. Differences were not statistically significant in the subgroup analysis that included only studies with low risk of bias. Immunogenic potential (risk of developing anti-drug antibodies) Biosimilars appear substantially equivalent to epoetin alfa in terms of Hb response and requirements for blood transfusion (see Summary of Findings 4). The quality of evidence supporting these findings is generally low. There are some concerns about the different potential risk for developing drug-associated antibodies, especially with regard to the interchangeability of originators and biosimilars and switching from one to the other. These concerns were addressed in a comprehensive systematic review of immunological reactions induced by treatment with biosimilar ESAs in patients with chronic kidney disease (13). The review included 14 RCTs and seven observational studies; 14 studies involved patients with end-stage renal disease undergoing dialysis. None of these studies indicated any important difference in efficacy between the original product and its biosimilar. Drug-associated antibodies were found in six of the 14 RCTs and six of the seven observational studies. However, the authors noted that inadequate and non-validated analytical methods were applied. No data were available on the clinical implications and reversibility of drug-associated antibodies and induction of resistance, and no data demonstrated immunological or clinical consequences of switching between products. Children Although children differ substantially from adults, those caring for adult and paediatric patients with chronic kidney disease share largely the same concerns regarding the diagnosis and management of anaemia. Since evidence in children is generally scarce and of low quality, generalization from evidence in adults is unavoidable. A 2010 review identified two RCTs in children with end-stage renal disease (26, 27); a 2014 review by the same authors included one additional study on darbepoetin (28). Additional information can be found in the Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease issued by the National Kidney Foundation, which include non-randomized studies and data from registries (21). The most robust evidence for using ESA products in children is related to epoetin alfa and beta, with some preliminary data on darbepoetin. Compared with epoetin in children with chronic kidney disease stages 4 and 5, darbepoetin alfa had uncertain effects on the need for blood transfusion and risk of progression to renal replacement therapy, all-cause mortality, hypertension, dialysis vascular access thrombosis, exceeding Hb target level and injection site pain, as well as Hb levels during treatment (18). Children in the North American Pediatric Renal Transplant Cooperative Study database from 1992 to 2001 with Hb lower than 9.9 g/dL compared with those with Hb more than 9.9 g/dL had a high risk for mortality (adjusted relative risk, 1.52; 95% CI 1.03–2.26). Patients with more severe anaemia also had an increased risk of hospitalization. In a multicentre single-arm interventional trial evaluating 22 children (4 months to 16 years) with chronic kidney disease, treatment of anaemia with recombinant erythropoietin was associated with a significant increase in intelligence quotient, although the relative increase in Hb levels was small (Hb baseline 9.2 ± 1.6 vs final 9.7 ± 1.7 g/dL) (21, 29).
The main safety concern linked to the use of ESAs in patients with chronic kidney disease is increases in the risk of death, myocardial infarction, stroke and other serious cardiovascular events. This is related to ESA doses targeting Hb of 11 g/dL and above. No trial has identified a Hb target level, ESA dose or dosing strategy that does not raise these risks. The lowest effective dose is therefore recommended (30). All proprietary ESAs raised the odds of hypertension compared with placebo, while the effect of biosimilar ESAs on hypertension was less certain (17). Since 2000, cases of aplasia (i.e. pure red cell aplasia, PRCA) and severe anaemia, with or without cytopenia, associated with neutralizing antibodies to erythropoietin, were reported in Europe and in USA, primarily in patients with chronic kidney disease given the medicine by SC injection. This was probably due to the interaction of stabilizing agent and part of the pre-filled syringes. Despite modifications in the pre-filled syringes new cases of antibody-associated PRCA are still reported, although the size of the phenomenon is limited (31). Based on time of exposure, PRCA incidence was 35.8/100 000 patient-years (95% CI 7.4–104.7) for epoetin alfa, 14.0/100 000 patient-years (95% CI 1.7–50.6) for epoetin beta and darbepoetin (11). No cases of PRCA emerged from the clinical development of biosimilars of epoetin alfa. However, sudden loss of efficacy and confirmed cases of PRCA were reported in a cluster of 23 Thai patients receiving regionally manufactured SC epoetin not approved in Europe (32, 33). High doses of erythropoietin may be associated with nephrogenic fibrosing dermopathy (34). A major issue in ESA use relates to the Hb target. It is generally known that targeting higher Hb levels in chronic kidney disease raises the risks for stroke, hypertension and vascular access thrombosis and probably increases the risks of death, serious cardiovascular events and end-stage renal disease (19). A systematic review with meta-regression of RCTs of ESAs in patients with chronic kidney disease examined whether a gradient of doses was associated with these potential harms, adjusting for the target or achieved Hb level (25). The authors identified an association between the first 3-month and total study period mean ESA dose and all-cause mortality, both in unadjusted models and models adjusting for target Hb. When restricting the analyses to dialysis patients, the association persisted in both the unadjusted and adjusted analyses. The lack of adjustment for other factors such as comorbidities and inflammatory markers, and inadequate control for treatment-by-indication bias and ecological fallacy, are limitations of this meta-regression analysis. In any case, these findings support the widely accepted use of more conservative dosing regimens for the treatment of patients with chronic kidney disease. Recent systematic reviews have suggested that aiming at Hb levels similar to those in healthy adults involves a significantly higher risk of all-cause mortality (16, 19). The first-generation ESAs (epoetin alfa and epoetin beta) have to be administered frequently, up to three times a week. This led to development of ESA agents with longer half-life (darbepoetin alfa, CERA) and consequent lower dosing frequency. The dosing schedules of darbepoetin once a week or once every 2 weeks and of CERA once a month offer many potential advantages to both patients and caregivers (35). However, the impact of these advantage should be considered in the light of the frequency of dialysis, which for most patients is three times a week. It remains unclear whether the new, longer-acting ESAs, given less frequently, offer the same efficacy and safety as older ESAs. A Cochrane systematic review updated in 2013 (16) sought to establish the optimal frequency of ESA administration. The review included 33 studies involving 5526 participants and concluded that longer-acting ESA (darbepoetin and CERA) given at 1–4-week intervals were non-inferior to ESA given 1–3 times a week in terms of achieving Hb targets, without any significant differences in adverse events in haemodialysis patients. The rapidly growing clinical experience with biosimilars has confirmed that their safety profile is in line with that of the reference products in terms of cardiovascular and thromboembolic events and immunogenicity data. In general, the known safety profile of ESAs as a class can be extended to biosimilars (36).
Cost / cost effectiveness
The application identified five cost-analyses. Four of them (37–40) and two HTA reports (22, 23) form the basis of the evidence reported here. Studies that evaluated different Hb targets showed that achieving higher Hb is not a cost-effective strategy, with mortality, hospitalization and utility estimates as major drivers of costs. When the initial Hb levels in haemodialysis patients were below 9 g/dL, providing epoetins in order to reach 10 to 11 g/dL was less costly and more effective than higher or lower Hb levels. Reported cost/QALY (quality-adjusted life- year) ratios ranged from US$ 931/QALY to US$ 677 749/QALY across five studies comparing ESAs with red blood cell transfusions. One retrospective study on the relative utilization and cost of ESAs in patients switched from epoetin to darbepoetin showed that the median dose:conversion ratio for each haemodialysis centre ranged from 288:1 to 400:1 and the average annual per-patient saving from US$ 2140 to US$ 4711. The authors concluded that switching patients from epoetin to darbepoetin maintained clinical benefits while considerably reducing costs. The study was conducted by independent researchers with an unrestricted grant from the darbepoetin producer (39). Another systematic review examined whether once-monthly CERA gave better cost–effectiveness or even cost saving compared with other ESAs. Review findings were contradictory, some demonstrating an increase in costs associated with CERA and others a cost reduction (40). It is expected that the introduction of biosimilars of epoetin will have an impact on prices and drug market. Price differences between biosimilars and originators has been broadly estimated at between 10% and 34%, although current evidence is limited (41). An estimate of biosimilar-related savings from 2007 to 2020 in eight European countries (Germany, France, Italy, Poland, Romania, Spain, Sweden and United Kingdom) was provided in a report supported by Sandoz Pharmaceuticals (42). On the basis of the data provided by IMS Health, the report evaluated how biosimilars can help in reducing health-care expenditure over the long term, through the increased use of biosimilars rather than originators. The estimated cumulative saving for biosimilar epoetins was €9.4–11.2 billion, subject to the expected market share trend and scenarios. The expected savings amount to 21.4–25.5% of the estimated €43.8 billion expenditure without the market entry of biosimilars. Cost saving should be weighted and evaluated considering the different penetration of biosimilars in different countries. IMS data up to 2011 showed that overall biosimilar sales are still a relatively small segment of the European market but that annual growth is strong. For epoetins, the highest uptake was reported in Germany, Greece and Sweden (43).
ESAs are licensed globally for treatment of symptomatic anaemia associated with chronic kidney disease. With the expiry of patent protection for epoetin alfa in Europe in 2007, biosimilar erythropoietins – e.g. epoetin alfa (Binocrit, Abseamed, Epoetin alfa Hexal), epoetin zeta (Retacrit, Silapo) – were introduced on the market (36). The patents on darbepoetin (Aranesp) expired in Europe in 2016 and will expire in USA in 2024 (42). Darbepoetin alfa “similar biologic” drugs (Actorise, Cresp, Darbatitor) are available in India (42). To be licensed in countries with stringent regulatory agencies, such as USA and countries of the European Union, a new epoetin claimed to be similar to a reference marketed product needs to undergo a proper comparability exercise, i.e. the head-to-head comparison, to establish similarity in quality, safety and efficacy (44). The stringent regulatory criteria and the need to provide a comprehensive data package have often been seen as putting an unnecessary burden (and cost) on the development and licensing processes, leading to delays in access to biosimilars. On the other hand, these criteria are meant to provide a sufficient level of evidence and extrapolation to reduce the concerns of both patients and health-care professionals about the use of biosimilars. Nevertheless, the adoption of such criteria is a matter of debate in clinical practice, with particular regard to the acceptability of switching from a reference drug to its biosimilars. However, pre-marketing trials and, above all, post-marketing drug-utilization data have helped, consolidating not only the therapeutic equivalence of the two products but also the safety of switching from reference to biosimilar products (45–47).
The application did not include peginesatide because of the safety concerns reported post-marketing, including serious hypersensitivity reactions such as anaphylaxis, which may be life-threatening or fatal. In 2013, the FDA recalled all lots of injectable peginesatide (Omontys) because of 19 reports of anaphylaxis (including three deaths) after the first dose in patients receiving dialysis (48).
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