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ATC codes: G03GB02
Indication
Female infertility without specification whether primary or secondary ICD11 code: GB4Z
INN
Clomifene
Medicine type
Chemical agent
List type
Complementary
Formulations
Oral > Solid: 50 mg (citrate)
EML status history
First added in 1979 (TRS 641)
Changed in 1984 (TRS 722)
Changed in 1993 (TRS 850)
Changed in 2003 (TRS 920)
Sex
Female
Age
Adolescents and adults
Therapeutic equivalence
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Wikipedia
DrugBank
Summary of evidence and Expert Committee recommendations
The Expert Committee noted that subfertility is a common problem which can cause considerable distress, that there is a Cochrane Review (1) that demonstrates the effectiveness of clomifene (NNT = 2.74) but no WHO clinical guidelines on infertility treatment, and thirdly, that clomifene is listed on 20 of 25 national essential medicines lists. The committee recommended that clomifene be retained on the Model List but moved to the complementary list (in view of the need for specialist care) and its square box symbol removed. 1. Hughes E, Collins J, Vandekerckhove P. Clomiphene citrate for ovulation induction in women with oligo- menorrhoea [abstract]. In: The Cochrane Library [online database and CD-ROM], Issue 1. Oxford, Update Software, 2003:AB000056 (http://www.update-software.com/abstracts/ab000056.htm).