ATC codes:
N05AD01
Indication
Schizophrenia or other primary psychotic disorders
ICD11 code:
6A4Z
INN
Haloperidol
Medicine type
Chemical agent
List type
Core
(EML)
Complementary (EMLc)
Complementary (EMLc)
Additional notes
The square box applies only to oral dose forms of haloperidol and chlorpromazine
Formulations
Parenteral > General injections > IM:
5 mg per mL in ampoule
Oral > Solid: 2 mg ; 5 mg
Oral > Solid: 2 mg ; 5 mg
EML status history
Sex
All
Age
Adolescents and adults
Therapeutic alternatives
chlorpromazine
(ATC codes: N05AA01)
Oral > Liquid: 25 mg per 5 mL (hydrochloride)
Oral > Solid: 100 mg (hydrochloride)
Oral > Liquid: 25 mg per 5 mL (hydrochloride)
Oral > Solid: 100 mg (hydrochloride)
Patent information
Patents have expired in most jurisdictions
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Wikipedia
DrugBank
Summary of evidence and Expert Committee recommendations
The Expert Committee recalled the request made by the 2021 Committee that therapeutic alternatives for the square box listings for chlorpromazine, fluphenazine and haloperidol in this section of the EML be reviewed. The Expert Committee accepted the rationale applied by the WHO Department of Mental Health and Substance Use in identifying suitable therapeutic alternatives, and made the following recommendations:
- Chlorpromazine (oral formulations only) be included as a therapeutic alternative to oral haloperidol. (This recommendation, coupled with the recommendation above to remove chlorpromazine injection, effectively removes the independent listing for chlorpromazine from the EML).
- Haloperidol decanoate and zuclopenthixol decanoate be included as therapeutic alternatives to fluphenazine (decanoate/enantate).
The Expert Committee recommended the deletion of chlorpromazine and haloperidol (all dosage forms) from the complementary list of the EMLc. The Committee noted that schizophrenia and other chronic psychotic disorders are rare in children younger than 12 years. The Committee agreed that the available evidence for these medicines in the treatment of psychoses in children was inconclusive and insufficient to support their ongoing inclusion on the EMLc.