The Expert Committee recommended the addition of a square box to the listing of risperidone on the EML for treatment of schizophrenia and related chronic psychotic disorders, specifying oral aripiprazole, olanzapine, paliperidone and quetiapine as therapeutic alternatives. The Committee noted that evidence from several high-quality meta-analyses on the acute and maintenance treatment of schizophrenia and other chronic psychoses that found most oral second-generation antipsychotics were similarly effective and tolerable.