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Essential medicine status
ATC codes: N05BA01
EMLc
Indication
Status epilepticus ICD11 code: 8A66.Z
INN
Diazepam
Medicine type
Chemical agent
List type
Core
Formulations
Local > Rectal > Gel: 5 mg per mL in 0.5 mL tubes ; 5 mg per mL in 2 mL tubes ; 5 mg per mL in 4 mL tubes
Local > Rectal > Solution: 5 mg per mL in 0.5 mL tubes ; 5 mg per mL in 2 mL tubes ; 5 mg per mL in 4 mL tubes
EML status history
First added in 1977 (TRS 615)
Changed in 1979 (TRS 641)
Changed in 1984 (TRS 722)
Changed in 1987 (TRS 770)
Changed in 1989 (TRS 796)
Changed in 2007 (TRS 950)
Changed in 2009 (TRS 958)
Sex
All
Age
Also recommended for children
Therapeutic equivalence
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Wikipedia
DrugBank
Summary of evidence and Expert Committee recommendations
In consideration of an application proposing the addition of lorazepam and midazolam for the treatment of repetitive and prolonged convulsive seizures (including status epilpeticus), the Expert Committee recommended the inclusion of parenteral lorazepam with a square box to replace diazepam on the Model List based on its comparative effectiveness and safety with respect to other medicines for the management of prolonged convulsive seizures and status epilepticus in adults and children. The rectal formulation of diazepam was maintained because if is a commercially available preparation and offers an option for treatment of severe seizures in patients when intravenous access is not available.