ATC codes: J04AM02
Tuberculosis ICD11 code: 1B4Z
Isoniazid + rifampicin
Core WHO recommends and endorses the use of fixed-dose combinations and the development of appropriate new fixed-dose combinations, including modified dosage forms, non-refrigerated products and paediatric dosage forms of assured pharmaceutical quality.
Oral > Solid: 50 mg + 75 mg tablet (dispersible) (EMLc) ; 75 mg + 150 mg tablet (EML) ; 150 mg + 300 mg tablet (EML)
EML status history
Also recommended for children
The recommendation is for this specific medicine
Patents have expired in most jurisdictions
Read more about patents.
Summary of evidence and Expert Committee recommendations
The Expert Committee recommended the deletion of the 60 mg + 60 mg and 150 mg + 150 mg formulations of isoniazid + rifampicin for intermittent use three times weekly from the core list of the EML, noting the advice of the WHO Global TB Programme that their use is no longer recommended in current WHO guidelines based on evidence that patients who received three times weekly dosing had a higher risk of treatment failure, disease relapse and acquired drug resistance compared with patients who received daily dosing (1). References: 1. Guidelines for treatment of drug-susceptible tuberculosis and patient care, 2017 update. Geneva: World Health Organization; 2017.