ATC codes:
J04AK01
EMLc
Indication
Tuberculosis
ICD11 code:
1B4Z
INN
Pyrazinamide
Medicine type
Chemical agent
List type
Core
WHO recommends and endorses the use of fixed-dose combinations and the development of appropriate new fixed-dose combinations, including modified dosage forms, non-refrigerated products and paediatric dosage forms of assured pharmaceutical quality.
Formulations
Oral > Liquid:
30 mg per mL
(EMLc)
Oral > Solid: 400 mg tablet ; 150 mg tablet (dispersible) ; 150 mg tablet (scored)
Oral > Solid: 400 mg tablet ; 150 mg tablet (dispersible) ; 150 mg tablet (scored)
EML status history
Sex
All
Age
Also recommended for children
Therapeutic equivalence
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Read more
about patents.
Wikipedia
DrugBank
Summary of evidence and Expert Committee recommendations
There are no international data publicly available that describe the prevalence and incidence of TB in children under 15 years of age, and few clinical trials of treatment on children. However, TB is accepted as a public health priority and therefore treatment of it fulfi ls the criteria for essential medicines. All four medicines used in standard treatment are licensed for use in children. The EMLc Subcommittee endorsed all four and noted that an oral liquid form of all of them was available. The Subcommittee recommended that all of these single agents be added to the List (ethambutol 25 mg/ml, isoniazid 50 mg/5 ml, pyrazinamide 30 mg/ml, rifampicin 20 mg/ml).