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Bupivacaine
Essential medicine status
Section:
1. Anaesthetics, preoperative medicines and medical gases 1.2. Local anaesthetics
ATC codes: N01BB01
EMLc
Indication
Local anaesthetics ICD11 code: XM7Y85
INN
Bupivacaine
Medicine type
Chemical agent
List type
Core (EML)
(EMLc)
Formulations
Parenteral > Locoregional injections > Spinal anaesthesia: 0.5% in 4 mL ampoule (hydrochloride) + 7.5% glucose solution
Parenteral > General injections > unspecified: 0.25% in vial (hydrochloride) ; 0.5% in vial (hydrochloride)
EML status history
First added in 1977 (TRS 615)
Changed in 2007 (TRS 950)
Changed in 2021 (TRS 1035)
Sex
All
Age
Also recommended for children
Therapeutic alternatives
Medicines within the same pharmacological class can be used
Therapeutic alternatives limitations
Therapeutic alternatives to be reviewed (2023)
Therapeutic alternatives limitations for EMLc
Therapeutic alternatives to be reviewed (2023)
Patent information
Patents have expired in most jurisdictions
Wikipedia
Bupivacaine
DrugBank
Bupivacaine
Summary of evidence and Expert Committee recommendations
Following the review of square box listings on the EML and EMLc, the Expert Committee requested the therapeutic alternatives for bupivacaine be reviewed.