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ATC codes: P01CX03
EMLc
Indication
African trypanosomiasis ICD11 code: 1F51
INN
Eflornithine
Medicine type
Chemical agent
List type
Core To be used for the treatment of Trypanosoma brucei gambiense infection.
Formulations
Parenteral > General injections > IV: 200 mg per mL in 100 mL bottle (hydrochloride)
EML status history
First added in 1991 (TRS 825)
Changed in 2007 (TRS 946)
Changed in 2007 (TRS 950)
Sex
All
Age
Also recommended for children
Therapeutic equivalence
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Summary of evidence and Expert Committee recommendations
African trypanosomiasis is a major public health problem in affected countries. Medicines available for treating this infection are limited. Hence despite the toxicity profile, eflornithine is still used. There is a paucity of documented information specific to children and recommendations for adults are usually followed. The EMLc Subcommittee acknowledged that there is a lack of information on the effectiveness and safety of eflornithine in children, however the seriousness of the illness and experience of its use in the field means that there should be no change in the listing of this medicine. The Subcommittee therefore recommended that eflornithine be endorsed for the EMLc for treatment of second-stage African trypanosomiasis.