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ATC codes: P01CC01
EMLc
Indication
Chagas disease ICD11 code: 1F53.Z
INN
Nifurtimox
Medicine type
Chemical agent
List type
Core
Formulations
Oral > Solid: 30 mg tablet ; 120 mg tablet ; 250 mg tablet
EML status history
First added in 1977 (TRS 615)
Changed in 1979 (TRS 641)
Changed in 1982 (TRS 685)
Changed in 1987 (TRS 770)
Changed in 2003 (TRS 920)
Changed in 2007 (TRS 950)
Sex
All
Age
Also recommended for children
Therapeutic equivalence
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Wikipedia
DrugBank
Summary of evidence and Expert Committee recommendations
The EMLc Subcommittee noted that as with treatments for African trypanosomiasis, older drugs are the mainstay of treatment for American trypanosomiasis (Trypanosoma cruzi infection). There is little information on the effectiveness and safety of nifurtimox. The Subcommittee noted a review indicating that the Ministries of Health in Latin America had accepted both agents as specific chemotherapeutic agents for Trypanosoma cruzi infection in adults and children, to eliminate the parasite from those infected and for breaking transmission. The Subcommittee therefore recommended that nifurtimox be endorsed for the EMLc for the treatment of American trypanosomiasis (Trypanosoma cruzi infection). The Subcommittee recognized the need to look at the efficacy and safety of these medicines in children for the next meeting. Also there was a need to develop paediatric-appropriate forms of these medicines.