Export

Not recommended as an essential medicine
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ATC codes: N03AE01
Indication
Generalised myoclonic seizure ICD11 code: 8A68.5
INN
Clonazepam
Medicine type
Chemical agent
List type
Complementary
Formulations
Oral > Solid: 500 µg
EML status history
First added in 1995 (TRS 867)
Removed in 2005 (TRS 933)
Sex
All
Age
Adolescents and adults
Therapeutic alternatives
Medicines within the same pharmacological class can be used
Therapeutic alternatives limitations
Clobazam
Patent information
Patents have expired in most jurisdictions
Wikipedia
DrugBank
Summary of evidence and Expert Committee recommendations
During its meeting in 2003, the Committee recommended that clonazepam be reviewed for possible fast-track deletion at the meeting in 2005. A detailed review was provided by the ISDB. The Committee noted that there was inadequate evidence to support the efficacy of clonazepam in the treatment of myoclonic epilepsy. The ISDB review indicated that valproate is the therapy of first choice. This review also indicated that clonazepam may have a place as a second-line drug for the treatment of refractory myoclonic seizures, but no clinical trial is available to support the retention of this item in the Model List. The Expert Committee recommended that clonazepam be deleted because of the lack of evidence of better efficacy or safety when compared with valproate.