Summary of evidence and Expert Committee recommendations
Midazolam, with a square box, was added to the core list of Section 1.3 of the EML and EMLc (Preoperative medication and sedation for short term procedures) in 2011, replacing diazepam. The Expert Committee noted that there was a large body of evidence to support its safety and efficacy, its wide availability, and relatively low cost.
Midazolam may be as safe as, but more effective than, diazepam for short-term procedures, due to its short duration of action and amnesic properties. Midazolam has better efficacy than promethazine in children in the preoperative setting.