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ATC codes: J01DD04
EMLc
Indication
Endophthalmitis ICD11 code: 9C21
INN
Ceftriaxone
Medicine type
Chemical agent
Antibiotic groups
List type
Core
Additional notes
Do not administer with calcium and avoid in infants with hyperbilirubinaemia.
Formulations
Parenteral > General injections > IV: 250 mg in vial powder for injection (as sodium salt) ; 1 g in vial powder for injection (as sodium salt) ; 2 g in vial powder for injection (as sodium salt) (EML)
EML status history
First added in 2021
Sex
All
Age
Also recommended for children
Age restriction
> 41 weeks corrected gestational age
Therapeutic alternatives
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Wikipedia
DrugBank
Expert Committee recommendation
The Expert Committee noted that infections of the eye and surrounding structures are frequent around the world and are an important cause of blindness. Given increasing concerns about overuse of antibiotics, the emergence of antimicrobial resistance and the need to guarantee prompt access to highly beneficial treatments, the Expert Committee noted the importance of revising and updating the Model Lists to provide clear information on the use of antibiotics in ocular infections. For endophthalmitis, the Committee acknowledged the lack of high-quality evidence for antibiotic choice and specific recommendations in guidelines. Based on common practice and the range of pathogens, the application proposed ceftriaxone plus vancomycin for systemic treatment, and vancomycin and ceftazidime by intravitreal administration for the empiric treatment of bacterial endophthalmitis. The Committee acknowledged that intravitreal treatment requires specialist training and adequate infrastructure to ensure safe administration. Given that bacterial endophthalmitis is a serious, sight-threatening infection, the Expert Committee recommended the current listings for ceftazidime, ceftriaxone and vancomycin be extended to include the indication of bacterial endophthalmitis as first-choice treatment options.
EML recommendations: Endophthalmitis
First choice
Second choice
First choice
ceftazidime co-prescribed with vancomycin
ceftriaxone co-prescribed with vancomycin
Second choice