Summary of evidence and Expert Committee recommendations
The Committee recommended deletion of zidovudine 60 mg dispersible scored tablet from the EMLc, noting they are no longer included in the current WHO guidelines for paediatric HIV treatment, and that suitable alternatives are already included on the Model Lists and available for use.
Zidovudine oral solution 50 mg/5mL remains included on the Model Lists for postnatal prophylaxis or neonatal use.
Zidovudine in fixed-dose combination with nevirapine and/or lamivudine remains included on the Model Lists.
Recommendations were made by the WHO HIV Department to delete the antiretroviral formulations from the EML and EMLc in order to achieve alignment between the 2018 WHO interim guidelines for antiretroviral regimens (1), and The 2018 optimal formulary and limited-use list for paediatric ARVs (2).
Zidovudine (AZT) 60 mg dispersible scored tablet was removed from the latest limited-use list. Zidovudine 60 mg is available in dual fixed-dose combination formulations with lamivudine that can be combined with an abacavir 60 mg dispersible scored tablet to deliver a triple nucleoside regimen during TB treatment.