ATC codes: N03AG01
Status epilepticus ICD11 code: 8A66
Valproic acid
Medicine type
Chemical agent
List type
Complementary (EML)
Additional notes
Avoid use in pregnancy and in women and girls of child-bearing potential, unless alternative treatments are ineffective or not tolerated because of the high risk of birth defects and developmental disorders in children exposed to valproate in the womb.
Parenteral > General injections > IV: 100 mg per mL in 4 mL ampoule ; 100 mg per mL in 10 mL ampoule ; 100 mg per mL in 3 mL ampoule
EML status history
First added in 2015 (TRS 994)
Changed in 2021 (TRS 1035)
Changed in 2023 (TRS 1049)
Also recommended for children
Therapeutic alternatives
The recommendation is for this specific medicine
Patent information
Patents have expired in most jurisdictions
Summary of evidence and Expert Committee recommendations
Following the review of the age-appropriateness of formulations on the EMLc, the Expert Committee recommended the inclusion of an additional vial size of valproic acid injection (100 mg/mL in 3 mL) on the EML and EMLc.