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ATC codes: J01CF02
EMLc
Indication
Sepsis without septic shock ICD11 code: 1G40
INN
Cloxacillin
Medicine type
Chemical agent
Antibiotic groups
List type
Core
Additional notes
*cloxacillin, dicloxacillin and flucloxacillin are preferred for oral administration due to better bioavailability
Formulations
Oral > Liquid: 125 mg per 5 mL (as sodium salt) powder for oral liquid (EMLc) ; 250 mg per 5 mL (as sodium salt) powder for oral liquid (EMLc)
Parenteral > General injections > unspecified: 500 mg in vial (as sodium salt) powder for injection (EMLc) ; 250 mg in vial (as sodium salt) powder for injection (EMLc)
Oral > Solid > capsule: 500 mg (as sodium salt) (EMLc) ; 1 g (as sodium salt) (EMLc) ; 250 mg (as sodium salt) (EMLc)
EML status history
First added in 2017 (TRS 1006)
Changed in 2021 (TRS 1035)
Changed in 2023 (TRS 1049)
Sex
All
Age
Children (1 month - 12 years)
Therapeutic alternatives
Medicines within the same pharmacological class can be used
Therapeutic alternatives limitations
Therapeutic alternatives are medicines in the 4th level ATC chemical subgroup: J01CF Beta-lactamase resistant penicillins.
Therapeutic alternatives limitations for EMLc
Therapeutic alternatives are medicines in the 4th level ATC chemical subgroup: J01CF Beta-lactamase resistant penicillins.
Patent information
Patents have expired in most jurisdictions
Wikipedia
DrugBank
Expert Committee recommendation
Following the review of the age-appropriateness of formulations on the EMLc, the Expert Committee recommended: - the addition of a new strength formulation of amikacin (injection 50 mg/mL (as sulfate) in 2 mL vial) to the EMLc. - the addition of new formulations of amoxicillin (dispersible, scored tablet, 250 mg and 500 mg) to the EMLc. - the addition of new strength formulations of cefotaxime (powder for injection: 500 mg; 1 g; 2 g (as sodium) in vial) to the EML and EMLc. - the addition of a new strength formulation of ceftriaxone (powder for injection: 500 mg (as sodium) in vial) to the EML and EMLc. - the addition of new strength formulations of cloxacillin (capsule 250 mg, powder for injection 250 mg (as sodium) and powder for oral liquid 250 mg/5 mL (as sodium) on the EMLc.
EML recommendations: Sepsis without septic shock
First choice
Second choice
First choice
Second choice